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Assay Detail

CHEMBL1963693

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: JAK2
ChEMBL ↗
853
Total Activities
838
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase JAK2 (CHEMBL2971) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 853 6.47 9.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1992073 — — 1 9.90
CHEMBL1987034 — — 1 9.10
CHEMBL2002099 — — 2 9.10
CHEMBL1980995 — — 1 9.10
CHEMBL1966175 — — 1 9.10
CHEMBL1993661 — — 1 9.10
CHEMBL1992342 — — 1 8.80
CHEMBL1997924 — — 1 8.70
CHEMBL1967998 — — 1 8.60
CHEMBL21156 — — 1 8.60
CHEMBL1979690 — — 1 8.60
CHEMBL234085 — — 1 8.40
CHEMBL1988838 — — 1 8.40
CHEMBL1994669 — — 1 8.40
CHEMBL2005886 — — 1 8.40
CHEMBL1983111 — — 1 8.40
CHEMBL1993424 — — 1 8.30
CHEMBL1980329 — — 1 8.30
CHEMBL2000393 — — 1 8.30
CHEMBL1971029 — — 1 8.30
CHEMBL1984548 — — 1 8.20
CHEMBL1982476 — — 1 8.00
CHEMBL1967878 CENISERTIB 2.0 1 8.00
CHEMBL1988163 — — 1 7.90
CHEMBL1975128 — — 1 7.90
CHEMBL2005449 — — 1 7.90
CHEMBL2006564 — — 1 7.90
CHEMBL1973893 — — 1 7.90
CHEMBL1969502 — — 1 7.80
CHEMBL491758 — — 1 7.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1992073 — Ki = 0.1259 nM 9.90
CHEMBL1987034 — Ki = 0.7943 nM 9.10
CHEMBL1993661 — Ki = 0.7943 nM 9.10
CHEMBL1966175 — Ki = 0.7943 nM 9.10
CHEMBL2002099 — Ki = 0.7943 nM 9.10
CHEMBL1980995 — Ki = 0.7943 nM 9.10
CHEMBL1992342 — Ki = 1.585 nM 8.80
CHEMBL1997924 — Ki = 1.995 nM 8.70
CHEMBL1967998 — Ki = 2.512 nM 8.60
CHEMBL1979690 — Ki = 2.512 nM 8.60
CHEMBL21156 — Ki = 2.512 nM 8.60
CHEMBL2002099 — Ki = 3.162 nM 8.50
CHEMBL2005886 — Ki = 3.981 nM 8.40
CHEMBL1983111 — Ki = 3.981 nM 8.40
CHEMBL1988838 — Ki = 3.981 nM 8.40
CHEMBL1994669 — Ki = 3.981 nM 8.40
CHEMBL234085 — Ki = 3.981 nM 8.40
CHEMBL1971029 — Ki = 5.012 nM 8.30
CHEMBL2000393 — Ki = 5.012 nM 8.30
CHEMBL1993424 — Ki = 5.012 nM 8.30
CHEMBL1980329 — Ki = 5.012 nM 8.30
CHEMBL1984548 — Ki = 6.31 nM 8.20
CHEMBL1967878 CENISERTIB Ki = 10.0 nM 8.00
CHEMBL1982476 — Ki = 10.0 nM 8.00
CHEMBL1988163 — Ki = 12.59 nM 7.90
CHEMBL2005449 — Ki = 12.59 nM 7.90
CHEMBL1973893 — Ki = 12.59 nM 7.90
CHEMBL1975128 — Ki = 12.59 nM 7.90
CHEMBL2006564 — Ki = 12.59 nM 7.90
CHEMBL1969502 — Ki = 15.85 nM 7.80
CHEMBL491758 — Ki = 15.85 nM 7.80
CHEMBL1975927 — Ki = 15.85 nM 7.80
CHEMBL1978099 — Ki = 19.95 nM 7.70
CHEMBL1970083 — Ki = 19.95 nM 7.70
CHEMBL1965660 — Ki = 19.95 nM 7.70
CHEMBL1983268 ENTRECTINIB Ki = 19.95 nM 7.70
CHEMBL1965660 — Ki = 19.95 nM 7.70
CHEMBL2006765 — Ki = 25.12 nM 7.60
CHEMBL1241473 — Ki = 25.12 nM 7.60
CHEMBL1983923 — Ki = 25.12 nM 7.60
CHEMBL244378 — Ki = 31.62 nM 7.50
CHEMBL1969588 — Ki = 31.62 nM 7.50
CHEMBL243088 — Ki = 31.62 nM 7.50
CHEMBL1983715 — Ki = 31.62 nM 7.50
CHEMBL1999484 — Ki = 31.62 nM 7.50
CHEMBL1987054 — Ki = 31.62 nM 7.50
CHEMBL1984162 — Ki = 39.81 nM 7.40
CHEMBL396523 — Ki = 39.81 nM 7.40
CHEMBL1972221 — Ki = 39.81 nM 7.40
CHEMBL49120 PD-0166285 Ki = 39.81 nM 7.40