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Compound Detail

CHEMBL1972221

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CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(NC(=O)CC)c3c2)cc1

Basic Information

ChEMBL ID CHEMBL1972221
Phase Preclinical
Structure Type MOL
InChI Key OEKYVFZKBRIDJO-UHFFFAOYSA-N
30
Targets
30
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

386.5
MW (Da)
3.73
ALogP
4
HBA
3
HBD
104.0
PSA (Ų)
0.58
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H22N4O3S
MW 386.48
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.63

Activity Summary

Ki 30 meas. best 7.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glycogen synthase kinase-3 alpha
CHEMBL2850
Ki 7.5 7.5 31.6 1
Tyrosine-protein kinase JAK2
CHEMBL2971
Ki 7.4 7.4 39.8 1
Cyclin-dependent kinase 2
CHEMBL301
Ki 7.2 7.2 63.1 1
Glycogen synthase kinase-3 beta
CHEMBL262
Ki 7.2 7.2 63.1 1
Non-receptor tyrosine-protein kinase TYK2
CHEMBL3553
Ki 7.1 7.1 79.4 1
Cyclin-dependent kinase 1
CHEMBL308
Ki 6.8 6.8 158.5 1
Tyrosine-protein kinase JAK3
CHEMBL2148
Ki 6.6 6.6 251.2 1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CHEMBL2292
Ki 6.5 6.5 316.2 1
Death-associated protein kinase 3
CHEMBL2468
Ki 6.4 6.4 398.1 1
Dual specificity protein kinase CLK4
CHEMBL4203
Ki 6.4 6.4 398.1 1
Cyclin-dependent kinase 5
CHEMBL4036
Ki 6.4 6.4 398.1 1
Serine/threonine-protein kinase 17A
CHEMBL4525
Ki 6.1 6.1 794.3 1
Mitogen-activated protein kinase 8
CHEMBL2276
Ki 5.9 5.9 1258.9 1
Aurora kinase A
CHEMBL4722
Ki 5.8 5.8 1584.9 1
Dual specificity protein kinase CLK2
CHEMBL4225
Ki 5.7 5.7 1995.3 1
Serine/threonine-protein kinase PLK4
CHEMBL3788
Ki 5.7 5.7 1995.3 1
Mitogen-activated protein kinase 9
CHEMBL4179
Ki 5.7 5.7 1995.3 1
Mitogen-activated protein kinase 1
CHEMBL4040
Ki 5.7 5.7 1995.3 1
Casein kinase I isoform gamma-1
CHEMBL2426
Ki 5.6 5.6 2511.9 1
Mitogen-activated protein kinase 12
CHEMBL4674
Ki 5.6 5.6 2511.9 1
Homeodomain-interacting protein kinase 4
CHEMBL1075167
Ki 5.6 5.6 2511.9 1
Dual specificity tyrosine-phosphorylation-regulated kinase 3
CHEMBL4575
Ki 5.3 5.3 5011.9 1
Mitogen-activated protein kinase 13
CHEMBL2939
Ki 5.3 5.3 5011.9 1
LIM domain kinase 1
CHEMBL3836
Ki 5.2 5.2 6309.6 1
Aurora kinase B
CHEMBL2185
Ki 5.2 5.2 6309.6 1
Ribosomal protein S6 kinase beta-1
CHEMBL4501
Ki 5.2 5.2 6309.6 1
Serine/threonine-protein kinase N2
CHEMBL3032
Ki 5.2 5.2 6309.6 1
Protein kinase C gamma type
CHEMBL2938
Ki 5.1 5.1 7943.3 1
Serine/threonine-protein kinase TAO1
CHEMBL5261
Ki 5.1 5.1 7943.3 1
Serine/threonine-protein kinase Sgk2
CHEMBL5794
Ki 5.1 5.1 7943.3 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Glycogen synthase kinase-3 alpha Ki = 31.62 nM 7.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Tyrosine-protein kinase JAK2 Ki = 39.81 nM 7.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Cyclin-dependent kinase 2 Ki = 63.1 nM 7.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Glycogen synthase kinase-3 beta Ki = 63.1 nM 7.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Non-receptor tyrosine-protein kinase TYK2 Ki = 79.43 nM 7.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Cyclin-dependent kinase 1 Ki = 158.49 nM 6.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Tyrosine-protein kinase JAK3 Ki = 251.19 nM 6.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Ki = 316.23 nM 6.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Death-associated protein kinase 3 Ki = 398.11 nM 6.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Cyclin-dependent kinase 5 Ki = 398.11 nM 6.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Dual specificity protein kinase CLK4 Ki = 398.11 nM 6.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Serine/threonine-protein kinase 17A Ki = 794.33 nM 6.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Mitogen-activated protein kinase 8 Ki = 1258.93 nM 5.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Aurora kinase A Ki = 1584.89 nM 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Dual specificity protein kinase CLK2 Ki = 1995.26 nM 5.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Mitogen-activated protein kinase 9 Ki = 1995.26 nM 5.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Mitogen-activated protein kinase 1 Ki = 1995.26 nM 5.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Serine/threonine-protein kinase PLK4 Ki = 1995.26 nM 5.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Casein kinase I isoform gamma-1 Ki = 2511.89 nM 5.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Homeodomain-interacting protein kinase 4 Ki = 2511.89 nM 5.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -

Data from ChEMBL 36 via Core Engine