Assay Detail
Functional
CHEMBL1963705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PLK4
704
Total Activities
693
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | other |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PLK4 (CHEMBL3788) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 704 | 6.45 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1984162 | — | — | 1 | 8.70 |
| CHEMBL509032 | TAE-684 | — | 1 | 8.50 |
| CHEMBL1993661 | — | — | 1 | 8.50 |
| CHEMBL458997 | — | — | 1 | 8.40 |
| CHEMBL1983111 | — | — | 1 | 8.20 |
| CHEMBL1967878 | CENISERTIB | 2.0 | 1 | 8.20 |
| CHEMBL1981047 | — | — | 1 | 8.20 |
| CHEMBL244378 | — | — | 1 | 8.10 |
| CHEMBL1994321 | — | — | 1 | 8.10 |
| CHEMBL1980995 | — | — | 1 | 8.10 |
| CHEMBL1964399 | — | — | 1 | 8.10 |
| CHEMBL1980297 | ILORASERTIB | 2.0 | 1 | 8.00 |
| CHEMBL1980144 | — | — | 1 | 8.00 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 8.00 |
| CHEMBL1241473 | — | — | 1 | 8.00 |
| CHEMBL1988594 | — | — | 1 | 8.00 |
| CHEMBL396523 | — | — | 1 | 7.90 |
| CHEMBL1980391 | RG-1530 | 1.0 | 1 | 7.90 |
| CHEMBL1971029 | — | — | 1 | 7.90 |
| CHEMBL1973540 | — | — | 1 | 7.90 |
| CHEMBL2000335 | — | — | 1 | 7.90 |
| CHEMBL1965507 | — | — | 1 | 7.90 |
| CHEMBL1967116 | — | — | 1 | 7.90 |
| CHEMBL2005886 | — | — | 1 | 7.90 |
| CHEMBL1970142 | — | — | 1 | 7.80 |
| CHEMBL1970317 | — | — | 1 | 7.80 |
| CHEMBL1972576 | — | — | 1 | 7.80 |
| CHEMBL1969523 | — | — | 1 | 7.80 |
| CHEMBL1987034 | — | — | 1 | 7.70 |
| CHEMBL1970203 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1984162 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL1993661 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL509032 | TAE-684 | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL458997 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1967878 | CENISERTIB | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1983111 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1981047 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1964399 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL244378 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1980995 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1994321 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1988594 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1241473 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1980144 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1980297 | ILORASERTIB | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL475251 | R-406 | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1980391 | RG-1530 | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL2005886 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1973540 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL396523 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1967116 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1971029 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL2000335 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1965507 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1970317 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1972576 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1969523 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1970142 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1987034 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL243088 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1970203 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1988437 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL302449 | GO-6976 | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL482967 | CYC-116 | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL572878 | TOZASERTIB | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1982466 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL491758 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1983923 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1988387 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1997129 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1999931 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL2002165 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1975128 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL483158 | ALISERTIB | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL2004716 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL260092 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1983268 | ENTRECTINIB | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1825138 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1982476 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1979057 | — | Ki | = | 39.81 | nM | 7.40 |