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Assay Detail

CHEMBL1963742

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: JAK3
ChEMBL ↗
900
Total Activities
884
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase JAK3 (CHEMBL2148) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 900 6.34 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL302449 GO-6976 — 1 9.20
CHEMBL1980995 — — 1 8.70
CHEMBL1994669 — — 1 8.50
CHEMBL1966175 — — 1 8.50
CHEMBL1992073 — — 1 8.40
CHEMBL2000393 — — 1 8.30
CHEMBL234085 — — 1 8.30
CHEMBL1993661 — — 1 8.20
CHEMBL1987034 — — 1 8.20
CHEMBL1993424 — — 1 8.10
CHEMBL1969588 — — 1 8.10
CHEMBL244378 — — 1 8.00
CHEMBL1984162 — — 1 8.00
CHEMBL1971029 — — 1 7.90
CHEMBL1988163 — — 1 7.70
CHEMBL1979690 — — 1 7.70
CHEMBL396523 — — 1 7.70
CHEMBL1980329 — — 1 7.70
CHEMBL1980407 — — 1 7.70
CHEMBL1983111 — — 1 7.60
CHEMBL1973540 — — 1 7.60
CHEMBL243088 — — 1 7.60
CHEMBL1969879 — — 1 7.50
CHEMBL2002346 — — 1 7.50
CHEMBL1998432 — — 1 7.40
CHEMBL21156 — — 1 7.40
CHEMBL1986943 — — 2 7.30
CHEMBL1973893 — — 1 7.30
CHEMBL1976936 — — 1 7.30
CHEMBL2001751 — — 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL302449 GO-6976 Ki = 0.631 nM 9.20
CHEMBL1980995 — Ki = 1.995 nM 8.70
CHEMBL1994669 — Ki = 3.162 nM 8.50
CHEMBL1966175 — Ki = 3.162 nM 8.50
CHEMBL1992073 — Ki = 3.981 nM 8.40
CHEMBL234085 — Ki = 5.012 nM 8.30
CHEMBL2000393 — Ki = 5.012 nM 8.30
CHEMBL1993661 — Ki = 6.31 nM 8.20
CHEMBL1987034 — Ki = 6.31 nM 8.20
CHEMBL1993424 — Ki = 7.943 nM 8.10
CHEMBL1969588 — Ki = 7.943 nM 8.10
CHEMBL1984162 — Ki = 10.0 nM 8.00
CHEMBL244378 — Ki = 10.0 nM 8.00
CHEMBL1971029 — Ki = 12.59 nM 7.90
CHEMBL1979690 — Ki = 19.95 nM 7.70
CHEMBL1980407 — Ki = 19.95 nM 7.70
CHEMBL396523 — Ki = 19.95 nM 7.70
CHEMBL1980329 — Ki = 19.95 nM 7.70
CHEMBL1988163 — Ki = 19.95 nM 7.70
CHEMBL1973540 — Ki = 25.12 nM 7.60
CHEMBL243088 — Ki = 25.12 nM 7.60
CHEMBL1983111 — Ki = 25.12 nM 7.60
CHEMBL2002346 — Ki = 31.62 nM 7.50
CHEMBL1969879 — Ki = 31.62 nM 7.50
CHEMBL1998432 — Ki = 39.81 nM 7.40
CHEMBL21156 — Ki = 39.81 nM 7.40
CHEMBL1976936 — Ki = 50.12 nM 7.30
CHEMBL1996649 — Ki = 50.12 nM 7.30
CHEMBL1973893 — Ki = 50.12 nM 7.30
CHEMBL1986943 — Ki = 50.12 nM 7.30
CHEMBL1967878 CENISERTIB Ki = 50.12 nM 7.30
CHEMBL2001751 — Ki = 50.12 nM 7.30
CHEMBL1986943 — Ki = 50.12 nM 7.30
CHEMBL2005509 — Ki = 63.1 nM 7.20
CHEMBL1996980 — Ki = 63.1 nM 7.20
CHEMBL1967998 — Ki = 63.1 nM 7.20
CHEMBL1987054 — Ki = 63.1 nM 7.20
CHEMBL1973395 — Ki = 63.1 nM 7.20
CHEMBL1992342 — Ki = 63.1 nM 7.20
CHEMBL1241473 — Ki = 63.1 nM 7.20
CHEMBL1992220 — Ki = 79.43 nM 7.10
CHEMBL1982476 — Ki = 79.43 nM 7.10
CHEMBL1980391 RG-1530 Ki = 79.43 nM 7.10
CHEMBL1999931 — Ki = 79.43 nM 7.10
CHEMBL243298 — Ki = 79.43 nM 7.10
CHEMBL1982271 — Ki = 100.0 nM 7.00
CHEMBL2002099 — Ki = 100.0 nM 7.00
CHEMBL1980253 — Ki = 100.0 nM 7.00
CHEMBL1989856 — Ki = 100.0 nM 7.00
CHEMBL2005449 — Ki = 100.0 nM 7.00