Compound Detail
CHEMBL1966175
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Basic Information
| ChEMBL ID | CHEMBL1966175 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FHIVNWJIENRJBH-UHFFFAOYSA-N |
13
Targets
13
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
322.4
MW (Da)
2.08
ALogP
5
HBA
1
HBD
90.1
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 13 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL2971 | Ki | 9.1 | 9.1 | 0.8 | 1 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | Ki | 8.5 | 8.5 | 3.2 | 1 |
| Rho-associated protein kinase 1 CHEMBL3231 | Ki | 7.6 | 7.6 | 25.1 | 1 |
| Leucine-rich repeat serine/threonine-protein kinase 2 CHEMBL1075104 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| Serine/threonine-protein kinase N2 CHEMBL3032 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| cAMP-dependent protein kinase catalytic subunit PRKX CHEMBL5818 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha CHEMBL4101 | Ki | 6.3 | 6.3 | 501.2 | 1 |
| Calcium/calmodulin-dependent protein kinase type 1D CHEMBL5073 | Ki | 6.1 | 6.1 | 794.3 | 1 |
| Leukocyte tyrosine kinase receptor CHEMBL5627 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Tyrosine-protein kinase Lck CHEMBL258 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Glycogen synthase kinase-3 alpha CHEMBL2850 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine