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Assay Detail

CHEMBL1963765

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TYK2
ChEMBL ↗
634
Total Activities
633
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 634 6.57 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL302449 GO-6976 — 1 8.50
CHEMBL1987034 — — 1 8.20
CHEMBL1967878 CENISERTIB 2.0 1 8.20
CHEMBL1993661 — — 1 8.20
CHEMBL1983111 — — 1 7.90
CHEMBL1988163 — — 1 7.80
CHEMBL475251 R-406 2.0 1 7.80
CHEMBL1991078 — — 1 7.70
CHEMBL1973893 — — 1 7.60
CHEMBL1988838 — — 1 7.60
CHEMBL244378 — — 1 7.50
CHEMBL1992342 — — 1 7.50
CHEMBL396523 — — 1 7.50
CHEMBL243088 — — 1 7.30
CHEMBL1980391 RG-1530 1.0 1 7.30
CHEMBL234085 — — 1 7.30
CHEMBL2005886 — — 1 7.30
CHEMBL1978099 — — 1 7.20
CHEMBL2000393 — — 1 7.20
CHEMBL1972221 — — 1 7.10
CHEMBL482967 CYC-116 1.0 1 7.10
CHEMBL1971029 — — 1 7.10
CHEMBL1975128 — — 1 7.00
CHEMBL2002346 — — 1 7.00
CHEMBL1993424 — — 1 6.80
CHEMBL1966343 — — 1 6.80
CHEMBL1241473 — — 1 6.80
CHEMBL2006778 — — 1 6.70
CHEMBL1997597 — — 1 6.70
CHEMBL2004892 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL302449 GO-6976 Ki = 3.162 nM 8.50
CHEMBL1987034 — Ki = 6.31 nM 8.20
CHEMBL1967878 CENISERTIB Ki = 6.31 nM 8.20
CHEMBL1993661 — Ki = 6.31 nM 8.20
CHEMBL1983111 — Ki = 12.59 nM 7.90
CHEMBL475251 R-406 Ki = 15.85 nM 7.80
CHEMBL1988163 — Ki = 15.85 nM 7.80
CHEMBL1991078 — Ki = 19.95 nM 7.70
CHEMBL1973893 — Ki = 25.12 nM 7.60
CHEMBL1988838 — Ki = 25.12 nM 7.60
CHEMBL244378 — Ki = 31.62 nM 7.50
CHEMBL396523 — Ki = 31.62 nM 7.50
CHEMBL1992342 — Ki = 31.62 nM 7.50
CHEMBL2005886 — Ki = 50.12 nM 7.30
CHEMBL234085 — Ki = 50.12 nM 7.30
CHEMBL243088 — Ki = 50.12 nM 7.30
CHEMBL1980391 RG-1530 Ki = 50.12 nM 7.30
CHEMBL2000393 — Ki = 63.1 nM 7.20
CHEMBL1978099 — Ki = 63.1 nM 7.20
CHEMBL1971029 — Ki = 79.43 nM 7.10
CHEMBL482967 CYC-116 Ki = 79.43 nM 7.10
CHEMBL1972221 — Ki = 79.43 nM 7.10
CHEMBL2002346 — Ki = 100.0 nM 7.00
CHEMBL1975128 — Ki = 100.0 nM 7.00
CHEMBL1241473 — Ki = 158.49 nM 6.80
CHEMBL1993424 — Ki = 158.49 nM 6.80
CHEMBL1966343 — Ki = 158.49 nM 6.80
CHEMBL2006778 — Ki = 199.53 nM 6.70
CHEMBL1983923 — Ki = 199.53 nM 6.70
CHEMBL522892 DOVITINIB Ki = 199.53 nM 6.70
CHEMBL509032 TAE-684 Ki = 199.53 nM 6.70
CHEMBL1997597 — Ki = 199.53 nM 6.70
CHEMBL572878 TOZASERTIB Ki = 199.53 nM 6.70
CHEMBL2004892 — Ki = 199.53 nM 6.70
CHEMBL1973540 — Ki = 251.19 nM 6.60
CHEMBL1970104 — Ki = 251.19 nM 6.60
CHEMBL2003420 — Ki = 316.23 nM 6.50
CHEMBL1084546 PF-00562271 Ki = 316.23 nM 6.50
CHEMBL1974664 — Ki = 316.23 nM 6.50
CHEMBL385478 — Ki = 316.23 nM 6.50
CHEMBL1969502 — Ki = 316.23 nM 6.50
CHEMBL1988437 — Ki = 316.23 nM 6.50
CHEMBL1969588 — Ki = 316.23 nM 6.50
CHEMBL1967116 — Ki = 398.11 nM 6.40
CHEMBL219722 — Ki = 398.11 nM 6.40
CHEMBL1994241 — Ki = 398.11 nM 6.40
CHEMBL1999931 — Ki = 501.19 nM 6.30
CHEMBL1986263 — Ki = 501.19 nM 6.30
CHEMBL1982476 — Ki = 501.19 nM 6.30
CHEMBL1969102 — Ki = 501.19 nM 6.30