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Assay Detail

CHEMBL1963701

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKAA1
ChEMBL ↗
929
Total Activities
913
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5'-AMP-activated protein kinase catalytic subunit alpha-1 (CHEMBL4045) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 929 6.14 9.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 9.50
CHEMBL1967878 CENISERTIB 2.0 1 9.00
CHEMBL1980407 — — 1 8.50
CHEMBL1997924 — — 1 8.40
CHEMBL1973540 — — 1 8.40
CHEMBL1969588 — — 1 8.40
CHEMBL1993661 — — 1 8.20
CHEMBL1241473 — — 1 8.10
CHEMBL509032 TAE-684 — 1 8.00
CHEMBL1974870 — — 1 8.00
CHEMBL1998159 — — 1 7.90
CHEMBL1981047 — — 1 7.80
CHEMBL1987034 — — 1 7.70
CHEMBL1983111 — — 1 7.70
CHEMBL2001751 — — 1 7.70
CHEMBL474432 — — 1 7.60
CHEMBL1998121 — — 1 7.60
CHEMBL1997129 — — 1 7.50
CHEMBL539474 — — 1 7.50
CHEMBL1991063 — — 1 7.50
CHEMBL2002479 — — 1 7.40
CHEMBL1965836 — — 1 7.40
CHEMBL1969502 — — 1 7.40
CHEMBL1973720 — — 2 7.40
CHEMBL1988581 — — 1 7.30
CHEMBL1999484 — — 1 7.30
CHEMBL2005886 — — 1 7.20
CHEMBL1991078 — — 1 7.20
CHEMBL1972576 — — 1 7.20
CHEMBL1977138 — — 1 7.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 0.3162 nM 9.50
CHEMBL1967878 CENISERTIB Ki = 1.0 nM 9.00
CHEMBL1980407 — Ki = 3.162 nM 8.50
CHEMBL1969588 — Ki = 3.981 nM 8.40
CHEMBL1973540 — Ki = 3.981 nM 8.40
CHEMBL1997924 — Ki = 3.981 nM 8.40
CHEMBL1993661 — Ki = 6.31 nM 8.20
CHEMBL1241473 — Ki = 7.943 nM 8.10
CHEMBL509032 TAE-684 Ki = 10.0 nM 8.00
CHEMBL1974870 — Ki = 10.0 nM 8.00
CHEMBL1998159 — Ki = 12.59 nM 7.90
CHEMBL1981047 — Ki = 15.85 nM 7.80
CHEMBL1983111 — Ki = 19.95 nM 7.70
CHEMBL2001751 — Ki = 19.95 nM 7.70
CHEMBL1987034 — Ki = 19.95 nM 7.70
CHEMBL474432 — Ki = 25.12 nM 7.60
CHEMBL1998121 — Ki = 25.12 nM 7.60
CHEMBL1991063 — Ki = 31.62 nM 7.50
CHEMBL1997129 — Ki = 31.62 nM 7.50
CHEMBL539474 — Ki = 31.62 nM 7.50
CHEMBL2002479 — Ki = 39.81 nM 7.40
CHEMBL1965836 — Ki = 39.81 nM 7.40
CHEMBL1973720 — Ki = 39.81 nM 7.40
CHEMBL1969502 — Ki = 39.81 nM 7.40
CHEMBL1973720 — Ki = 39.81 nM 7.40
CHEMBL1999484 — Ki = 50.12 nM 7.30
CHEMBL1988581 — Ki = 50.12 nM 7.30
CHEMBL1972576 — Ki = 63.1 nM 7.20
CHEMBL1991078 — Ki = 63.1 nM 7.20
CHEMBL2005886 — Ki = 63.1 nM 7.20
CHEMBL1990885 — Ki = 63.1 nM 7.20
CHEMBL1999931 — Ki = 63.1 nM 7.20
CHEMBL1977138 — Ki = 63.1 nM 7.20
CHEMBL522892 DOVITINIB Ki = 79.43 nM 7.10
CHEMBL1969151 — Ki = 79.43 nM 7.10
CHEMBL1983715 — Ki = 100.0 nM 7.00
CHEMBL1983575 — Ki = 100.0 nM 7.00
CHEMBL1979690 — Ki = 100.0 nM 7.00
CHEMBL1971029 — Ki = 100.0 nM 7.00
CHEMBL1988594 — Ki = 100.0 nM 7.00
CHEMBL1967998 — Ki = 100.0 nM 7.00
CHEMBL1975128 — Ki = 100.0 nM 7.00
CHEMBL1988173 — Ki = 100.0 nM 7.00
CHEMBL2003638 — Ki = 100.0 nM 7.00
CHEMBL2002649 — Ki = 125.89 nM 6.90
CHEMBL1982957 — Ki = 125.89 nM 6.90
CHEMBL1986943 — Ki = 125.89 nM 6.90
CHEMBL1973516 — Ki = 125.89 nM 6.90
CHEMBL1986943 — Ki = 125.89 nM 6.90
CHEMBL1966628 — Ki = 125.89 nM 6.90