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Assay Detail

CHEMBL1963767

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCG
ChEMBL ↗
755
Total Activities
743
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Protein kinase C gamma type (CHEMBL2938) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 755 5.86 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 8.50
CHEMBL1974870 — — 1 8.20
CHEMBL1970903 — — 1 8.10
CHEMBL565612 SOTRASTAURIN 2.0 1 7.90
CHEMBL1991063 — — 1 7.80
CHEMBL1965836 — — 1 7.70
CHEMBL1969502 — — 1 7.50
CHEMBL2001751 — — 1 7.50
CHEMBL1965845 — — 1 7.40
CHEMBL302449 GO-6976 — 1 7.40
CHEMBL2000271 — — 1 7.30
CHEMBL1974328 — — 1 7.20
CHEMBL1999931 — — 1 7.10
CHEMBL1987034 — — 1 7.00
CHEMBL1991078 — — 1 6.90
CHEMBL1966628 — — 1 6.80
CHEMBL1986943 — — 2 6.70
CHEMBL592030 — — 1 6.70
CHEMBL1997534 — — 1 6.70
CHEMBL1967878 CENISERTIB 2.0 1 6.70
CHEMBL1993661 — — 1 6.70
CHEMBL1995813 — — 1 6.60
CHEMBL1965660 — — 2 6.60
CHEMBL220241 GSK-269962A — 1 6.60
CHEMBL475251 R-406 2.0 1 6.60
CHEMBL1991674 — — 1 6.60
CHEMBL2002726 — — 1 6.60
CHEMBL1988163 — — 1 6.50
CHEMBL1725279 SP-600125 — 1 6.50
CHEMBL1241473 — — 1 6.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 3.162 nM 8.50
CHEMBL1974870 — Ki = 6.31 nM 8.20
CHEMBL1970903 — Ki = 7.943 nM 8.10
CHEMBL565612 SOTRASTAURIN Ki = 12.59 nM 7.90
CHEMBL1991063 — Ki = 15.85 nM 7.80
CHEMBL1965836 — Ki = 19.95 nM 7.70
CHEMBL2001751 — Ki = 31.62 nM 7.50
CHEMBL1969502 — Ki = 31.62 nM 7.50
CHEMBL1965845 — Ki = 39.81 nM 7.40
CHEMBL302449 GO-6976 Ki = 39.81 nM 7.40
CHEMBL2000271 — Ki = 50.12 nM 7.30
CHEMBL1974328 — Ki = 63.1 nM 7.20
CHEMBL1999931 — Ki = 79.43 nM 7.10
CHEMBL1987034 — Ki = 100.0 nM 7.00
CHEMBL1991078 — Ki = 125.89 nM 6.90
CHEMBL1966628 — Ki = 158.49 nM 6.80
CHEMBL1967878 CENISERTIB Ki = 199.53 nM 6.70
CHEMBL592030 — Ki = 199.53 nM 6.70
CHEMBL1986943 — Ki = 199.53 nM 6.70
CHEMBL1986943 — Ki = 199.53 nM 6.70
CHEMBL1997534 — Ki = 199.53 nM 6.70
CHEMBL1993661 — Ki = 199.53 nM 6.70
CHEMBL475251 R-406 Ki = 251.19 nM 6.60
CHEMBL1991674 — Ki = 251.19 nM 6.60
CHEMBL1965660 — Ki = 251.19 nM 6.60
CHEMBL2002726 — Ki = 251.19 nM 6.60
CHEMBL1965660 — Ki = 251.19 nM 6.60
CHEMBL220241 GSK-269962A Ki = 251.19 nM 6.60
CHEMBL1995813 — Ki = 251.19 nM 6.60
CHEMBL2003638 — Ki = 316.23 nM 6.50
CHEMBL1991180 — Ki = 316.23 nM 6.50
CHEMBL1725279 SP-600125 Ki = 316.23 nM 6.50
CHEMBL1241473 — Ki = 316.23 nM 6.50
CHEMBL1988163 — Ki = 316.23 nM 6.50
CHEMBL1966524 — Ki = 398.11 nM 6.40
CHEMBL1969588 — Ki = 398.11 nM 6.40
CHEMBL1976240 — Ki = 501.19 nM 6.30
CHEMBL1993166 — Ki = 501.19 nM 6.30
CHEMBL2005886 — Ki = 501.19 nM 6.30
CHEMBL1997846 — Ki = 501.19 nM 6.30
CHEMBL1982122 — Ki = 501.19 nM 6.30
CHEMBL1991728 — Ki = 630.96 nM 6.20
CHEMBL1983268 ENTRECTINIB Ki = 630.96 nM 6.20
CHEMBL1971029 — Ki = 630.96 nM 6.20
CHEMBL340384 — Ki = 630.96 nM 6.20
CHEMBL1983111 — Ki = 794.33 nM 6.10
CHEMBL1975128 — Ki = 794.33 nM 6.10
CHEMBL2002479 — Ki = 794.33 nM 6.10
CHEMBL1970217 — Ki = 794.33 nM 6.10
CHEMBL1988608 — Ki = 794.33 nM 6.10