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Assay Detail

CHEMBL1963796

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: NEK4
ChEMBL ↗
602
Total Activities
593
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase Nek4 (CHEMBL5819) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 602 5.93 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1997129 — — 1 8.30
CHEMBL1241473 — — 1 8.20
CHEMBL1987034 — — 1 8.00
CHEMBL244378 — — 1 7.90
CHEMBL396523 — — 1 7.90
CHEMBL1993661 — — 1 7.80
CHEMBL1190711 — — 1 7.60
CHEMBL243088 — — 1 7.40
CHEMBL1965660 — — 2 7.30
CHEMBL497151 — — 1 7.30
CHEMBL1988163 — — 1 7.20
CHEMBL1990254 — — 2 7.10
CHEMBL1976240 — — 1 7.00
CHEMBL2000345 — — 1 6.90
CHEMBL1991063 — — 1 6.90
CHEMBL1981079 — — 1 6.80
CHEMBL1999931 — — 1 6.80
CHEMBL1983111 — — 1 6.70
CHEMBL592030 — — 1 6.70
CHEMBL475251 R-406 2.0 1 6.70
CHEMBL1980297 ILORASERTIB 2.0 1 6.70
CHEMBL482767 SNS-314 1.0 1 6.60
CHEMBL1965836 — — 1 6.60
CHEMBL1978448 — — 1 6.60
CHEMBL1994241 — — 1 6.60
CHEMBL1988838 — — 1 6.60
CHEMBL1974870 — — 1 6.60
CHEMBL1998159 — — 1 6.50
CHEMBL1988387 — — 1 6.50
CHEMBL458997 — — 1 6.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1997129 — Ki = 5.012 nM 8.30
CHEMBL1241473 — Ki = 6.31 nM 8.20
CHEMBL1987034 — Ki = 10.0 nM 8.00
CHEMBL396523 — Ki = 12.59 nM 7.90
CHEMBL244378 — Ki = 12.59 nM 7.90
CHEMBL1993661 — Ki = 15.85 nM 7.80
CHEMBL1190711 — Ki = 25.12 nM 7.60
CHEMBL243088 — Ki = 39.81 nM 7.40
CHEMBL497151 — Ki = 50.12 nM 7.30
CHEMBL1965660 — Ki = 50.12 nM 7.30
CHEMBL1965660 — Ki = 50.12 nM 7.30
CHEMBL1988163 — Ki = 63.1 nM 7.20
CHEMBL1990254 — Ki = 79.43 nM 7.10
CHEMBL1976240 — Ki = 100.0 nM 7.00
CHEMBL2000345 — Ki = 125.89 nM 6.90
CHEMBL1991063 — Ki = 125.89 nM 6.90
CHEMBL1981079 — Ki = 158.49 nM 6.80
CHEMBL1999931 — Ki = 158.49 nM 6.80
CHEMBL475251 R-406 Ki = 199.53 nM 6.70
CHEMBL1980297 ILORASERTIB Ki = 199.53 nM 6.70
CHEMBL1983111 — Ki = 199.53 nM 6.70
CHEMBL592030 — Ki = 199.53 nM 6.70
CHEMBL1978448 — Ki = 251.19 nM 6.60
CHEMBL482767 SNS-314 Ki = 251.19 nM 6.60
CHEMBL1994241 — Ki = 251.19 nM 6.60
CHEMBL1974870 — Ki = 251.19 nM 6.60
CHEMBL1990254 — Ki = 251.19 nM 6.60
CHEMBL1988838 — Ki = 251.19 nM 6.60
CHEMBL1965836 — Ki = 251.19 nM 6.60
CHEMBL1988387 — Ki = 316.23 nM 6.50
CHEMBL1981410 — Ki = 316.23 nM 6.50
CHEMBL1969523 — Ki = 316.23 nM 6.50
CHEMBL1998159 — Ki = 316.23 nM 6.50
CHEMBL1994830 — Ki = 316.23 nM 6.50
CHEMBL458997 — Ki = 316.23 nM 6.50
CHEMBL1986263 — Ki = 398.11 nM 6.40
CHEMBL1967878 CENISERTIB Ki = 398.11 nM 6.40
CHEMBL482967 CYC-116 Ki = 398.11 nM 6.40
CHEMBL1969301 — Ki = 501.19 nM 6.30
CHEMBL1973540 — Ki = 501.19 nM 6.30
CHEMBL1982924 — Ki = 630.96 nM 6.20
CHEMBL509032 TAE-684 Ki = 630.96 nM 6.20
CHEMBL1992634 — Ki = 630.96 nM 6.20
CHEMBL1982992 — Ki = 630.96 nM 6.20
CHEMBL1998585 — Ki = 794.33 nM 6.10
CHEMBL2003638 — Ki = 794.33 nM 6.10
CHEMBL1993424 — Ki = 794.33 nM 6.10
CHEMBL1992937 — Ki = 794.33 nM 6.10
CHEMBL1986943 — Ki = 794.33 nM 6.10
CHEMBL2006778 — Ki = 794.33 nM 6.10