Compound Detail
CHEMBL3893950
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COc1cc(OC)cc(N(CCNC[Si](C)(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1.Cl
Basic Information
| ChEMBL ID | CHEMBL3893950 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JMKXJKVYUUVONH-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3990499 |
| Active Moiety | CHEMBL3990499 |
6
Targets
10
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
490.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 10 meas. best 8.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.32 | 8.32 | 4.8 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.22 | 7.645 | 6.0 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.14 | 7.64 | 7.2 | 2 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.89 | 7.89 | 12.9 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.2 | 6.08 | 63.1 | 3 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.15 | 5.15 | 7079.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine