Compound Detail
CHEMBL3936673
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CCc1ccnc(C#CCN(c2cc(OC)cc(OC)c2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)n1
Basic Information
| ChEMBL ID | CHEMBL3936673 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HQQABXMYFDMKIT-UHFFFAOYSA-N |
6
Targets
12
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
505.6
MW (Da)
4.59
ALogP
9
HBA
0
HBD
91.1
PSA (Ų)
0.30
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 12 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.72 | 7.6 | 19.1 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.56 | 6.6667 | 27.5 | 3 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.36 | 7.36 | 43.6 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.17 | 7.17 | 67.6 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.26 | 5.48 | 549.5 | 3 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.12 | 5.06 | 7585.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine