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Assay Detail

CHEMBL1963753

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK22D
ChEMBL ↗
514
Total Activities
509
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Testis-specific serine/threonine-protein kinase 1 (CHEMBL6003) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 514 6.59 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1971029 — — 1 8.60
CHEMBL2001751 — — 1 8.20
CHEMBL1993661 — — 1 8.10
CHEMBL1995813 — — 1 7.80
CHEMBL1987034 — — 1 7.50
CHEMBL1998159 — — 1 7.50
CHEMBL509032 TAE-684 — 1 7.50
CHEMBL1983111 — — 1 7.30
CHEMBL220241 GSK-269962A — 1 7.30
CHEMBL1966628 — — 1 7.20
CHEMBL1969523 — — 1 7.20
CHEMBL1982957 — — 1 7.10
CHEMBL1974328 — — 1 7.10
CHEMBL2001239 — — 1 7.10
CHEMBL1974870 — — 1 7.00
CHEMBL1991063 — — 1 7.00
CHEMBL1967878 CENISERTIB 2.0 1 7.00
CHEMBL475251 R-406 2.0 1 7.00
CHEMBL1986943 — — 2 6.90
CHEMBL1241473 — — 1 6.90
CHEMBL1999931 — — 1 6.80
CHEMBL1975128 — — 1 6.70
CHEMBL1969588 — — 1 6.70
CHEMBL1996817 — — 1 6.70
CHEMBL1990885 — — 1 6.70
CHEMBL514499 GW843682X — 1 6.70
CHEMBL1997129 — — 1 6.60
CHEMBL1965836 — — 1 6.60
CHEMBL592030 — — 1 6.60
CHEMBL1997846 — — 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1971029 — Ki = 2.512 nM 8.60
CHEMBL2001751 — Ki = 6.31 nM 8.20
CHEMBL1993661 — Ki = 7.943 nM 8.10
CHEMBL1995813 — Ki = 15.85 nM 7.80
CHEMBL1987034 — Ki = 31.62 nM 7.50
CHEMBL1998159 — Ki = 31.62 nM 7.50
CHEMBL509032 TAE-684 Ki = 31.62 nM 7.50
CHEMBL1983111 — Ki = 50.12 nM 7.30
CHEMBL220241 GSK-269962A Ki = 50.12 nM 7.30
CHEMBL1966628 — Ki = 63.1 nM 7.20
CHEMBL1969523 — Ki = 63.1 nM 7.20
CHEMBL1982957 — Ki = 79.43 nM 7.10
CHEMBL2001239 — Ki = 79.43 nM 7.10
CHEMBL1974328 — Ki = 79.43 nM 7.10
CHEMBL1967878 CENISERTIB Ki = 100.0 nM 7.00
CHEMBL1991063 — Ki = 100.0 nM 7.00
CHEMBL475251 R-406 Ki = 100.0 nM 7.00
CHEMBL1974870 — Ki = 100.0 nM 7.00
CHEMBL1986943 — Ki = 125.89 nM 6.90
CHEMBL1241473 — Ki = 125.89 nM 6.90
CHEMBL1986943 — Ki = 125.89 nM 6.90
CHEMBL1999931 — Ki = 158.49 nM 6.80
CHEMBL1996817 — Ki = 199.53 nM 6.70
CHEMBL1975128 — Ki = 199.53 nM 6.70
CHEMBL1990885 — Ki = 199.53 nM 6.70
CHEMBL1969588 — Ki = 199.53 nM 6.70
CHEMBL514499 GW843682X Ki = 199.53 nM 6.70
CHEMBL1965836 — Ki = 251.19 nM 6.60
CHEMBL1997846 — Ki = 251.19 nM 6.60
CHEMBL592030 — Ki = 251.19 nM 6.60
CHEMBL1997129 — Ki = 251.19 nM 6.60
CHEMBL1973540 — Ki = 316.23 nM 6.50
CHEMBL2003638 — Ki = 501.19 nM 6.30
CHEMBL522892 DOVITINIB Ki = 501.19 nM 6.30
CHEMBL1970104 — Ki = 501.19 nM 6.30
CHEMBL1970104 — Ki = 501.19 nM 6.30
CHEMBL1981047 — Ki = 501.19 nM 6.30
CHEMBL1970903 — Ki = 501.19 nM 6.30
CHEMBL1992922 — Ki = 630.96 nM 6.20
CHEMBL392642 — Ki = 630.96 nM 6.20
CHEMBL2000071 — Ki = 630.96 nM 6.20
CHEMBL2002726 — Ki = 630.96 nM 6.20
CHEMBL1987009 — Ki = 794.33 nM 6.10
CHEMBL1998121 — Ki = 794.33 nM 6.10
CHEMBL2000354 — Ki = 794.33 nM 6.10
CHEMBL1964937 — Ki = 794.33 nM 6.10
CHEMBL1988163 — Ki = 794.33 nM 6.10
CHEMBL1996979 — Ki = 1000.0 nM 6.00
CHEMBL1965845 — Ki = 1000.0 nM 6.00
CHEMBL1970522 — Ki = 1000.0 nM 6.00