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Assay Detail

CHEMBL1963775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MET
ChEMBL ↗
924
Total Activities
910
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Hepatocyte growth factor receptor (CHEMBL3717) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 924 6.19 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1825138 — — 3 9.20
CHEMBL2001019 PF-04217903 1.0 1 9.20
CHEMBL1977148 — — 1 8.50
CHEMBL1965170 — — 1 8.40
CHEMBL1980297 ILORASERTIB 2.0 1 8.40
CHEMBL1967116 — — 1 8.10
CHEMBL1988581 — — 1 8.10
CHEMBL1970317 — — 1 8.10
CHEMBL1972220 — — 1 8.00
CHEMBL1982476 — — 1 8.00
CHEMBL1989708 — — 2 7.90
CHEMBL1979516 — — 1 7.90
CHEMBL1997129 — — 1 7.90
CHEMBL2002165 — — 1 7.90
CHEMBL2004290 — — 1 7.80
CHEMBL1993941 — — 1 7.70
CHEMBL1993661 — — 1 7.50
CHEMBL1974254 — — 1 7.50
CHEMBL1983111 — — 1 7.50
CHEMBL1241473 — — 1 7.40
CHEMBL1969102 — — 1 7.40
CHEMBL2005631 — — 1 7.40
CHEMBL1967720 — — 1 7.40
CHEMBL1973359 — — 1 7.30
CHEMBL1999414 — — 1 7.30
CHEMBL1988141 — — 1 7.30
CHEMBL1996649 — — 1 7.20
CHEMBL1970142 — — 1 7.20
CHEMBL1988387 — — 1 7.20
CHEMBL1982466 — — 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1825138 — Ki = 0.631 nM 9.20
CHEMBL2001019 PF-04217903 Ki = 0.631 nM 9.20
CHEMBL1977148 — Ki = 3.162 nM 8.50
CHEMBL1980297 ILORASERTIB Ki = 3.981 nM 8.40
CHEMBL1965170 — Ki = 3.981 nM 8.40
CHEMBL1967116 — Ki = 7.943 nM 8.10
CHEMBL1988581 — Ki = 7.943 nM 8.10
CHEMBL1970317 — Ki = 7.943 nM 8.10
CHEMBL1825138 — Ki = 10.0 nM 8.00
CHEMBL1972220 — Ki = 10.0 nM 8.00
CHEMBL1982476 — Ki = 10.0 nM 8.00
CHEMBL1997129 — Ki = 12.59 nM 7.90
CHEMBL2002165 — Ki = 12.59 nM 7.90
CHEMBL1979516 — Ki = 12.59 nM 7.90
CHEMBL1989708 — Ki = 12.59 nM 7.90
CHEMBL1825138 — Ki = 15.85 nM 7.80
CHEMBL2004290 — Ki = 15.85 nM 7.80
CHEMBL1993941 — Ki = 19.95 nM 7.70
CHEMBL1993661 — Ki = 31.62 nM 7.50
CHEMBL1974254 — Ki = 31.62 nM 7.50
CHEMBL1983111 — Ki = 31.62 nM 7.50
CHEMBL1967720 — Ki = 39.81 nM 7.40
CHEMBL1989708 — Ki = 39.81 nM 7.40
CHEMBL1969102 — Ki = 39.81 nM 7.40
CHEMBL2005631 — Ki = 39.81 nM 7.40
CHEMBL1241473 — Ki = 39.81 nM 7.40
CHEMBL1988141 — Ki = 50.12 nM 7.30
CHEMBL1973359 — Ki = 50.12 nM 7.30
CHEMBL1999414 — Ki = 50.12 nM 7.30
CHEMBL1970142 — Ki = 63.1 nM 7.20
CHEMBL1996649 — Ki = 63.1 nM 7.20
CHEMBL1988387 — Ki = 63.1 nM 7.20
CHEMBL1982466 — Ki = 79.43 nM 7.10
CHEMBL1982465 — Ki = 100.0 nM 7.00
CHEMBL1980995 — Ki = 100.0 nM 7.00
CHEMBL1991734 — Ki = 100.0 nM 7.00
CHEMBL1993722 — Ki = 100.0 nM 7.00
CHEMBL1972355 — Ki = 125.89 nM 6.90
CHEMBL1983640 — Ki = 125.89 nM 6.90
CHEMBL1966514 — Ki = 125.89 nM 6.90
CHEMBL474432 — Ki = 125.89 nM 6.90
CHEMBL2004716 — Ki = 125.89 nM 6.90
CHEMBL1164265 — Ki = 125.89 nM 6.90
CHEMBL1967998 — Ki = 125.89 nM 6.90
CHEMBL49120 PD-0166285 Ki = 158.49 nM 6.80
CHEMBL244378 — Ki = 158.49 nM 6.80
CHEMBL458997 — Ki = 199.53 nM 6.70
CHEMBL1983715 — Ki = 199.53 nM 6.70
CHEMBL1973540 — Ki = 199.53 nM 6.70
CHEMBL260092 — Ki = 199.53 nM 6.70