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Compound Detail

CHEMBL1330307

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Oc1c(C(Nc2ccccn2)c2ccccn2)ccc2cccnc12

Basic Information

ChEMBL ID CHEMBL1330307
Phase Preclinical
Structure Type MOL
InChI Key ODYWXTWUNZPEGJ-UHFFFAOYSA-N
6
Targets
15
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

328.4
MW (Da)
3.93
ALogP
5
HBA
2
HBD
70.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H16N4O
MW 328.38
Aromatic Rings 4
Heavy Atoms 25
NP-Likeness -1.08

Activity Summary

EC50 10 meas. best 5.91
IC50 5 meas. best 5.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 5.91 5.195 1220.0 6
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
CHEMBL2164
IC50 5.42 5.42 3824.0 1
Nuclear factor NF-kappa-B complex
CHEMBL2094258
EC50 5.4 5.4 3994.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.13 5.13 7437.0 1
Streptokinase A
CHEMBL1293228
EC50 4.97 4.97 10668.0 1
Unchecked
CHEMBL612545
IC50 4.94 4.41 11400.0 4
Streptococcus
CHEMBL612313
EC50 4.83 4.83 14815.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 1220.0 nM 5.91 PUBCHEM_BIOASSAY: Luminescence Cell-Based/Microorganism Dose Confirmation HTS to... -
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit IC50 = 3824.0 nM 5.42 PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response a... -
Nuclear factor NF-kappa-B complex EC50 = 3994.0 nM 5.4 PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increa... -
Unchecked EC50 = 4230.0 nM 5.37 PUBCHEM_BIOASSAY: A cytotoxicity screen of small molecule inhibitors of the PhoP... -
Unchecked EC50 = 5865.0 nM 5.23 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS Screen to Identify C... -
Streptococcus sp. 'group A' EC50 = 7437.0 nM 5.13 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Unchecked EC50 = 9902.0 nM 5.0 PUBCHEM_BIOASSAY: Luminescence Cell-Based Confirmation at Dose to Identify Trans... -
Streptokinase A EC50 = 10668.0 nM 4.97 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Unchecked IC50 = 11400.0 nM 4.94 PubChem BioAssay. Dose Response confirmation of small molecule inhibitors origin... -
Unchecked EC50 = 12300.0 nM 4.91 PUBCHEM_BIOASSAY: Dose response confirmation of small molecule activators of the... -
Streptococcus EC50 = 14815.0 nM 4.83 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... -
Unchecked EC50 = 17560.0 nM 4.75 PUBCHEM_BIOASSAY: Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cel... -
Unchecked IC50 = 40160.0 nM 4.4 PUBCHEM_BIOASSAY: A Counter Screen to identiry small molecule screen for inhibit... -
Unchecked IC50 = 55240.0 nM 4.26 PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi... -
Unchecked IC50 = 91570.0 nM 4.04 PUBCHEM_BIOASSAY: A small molecule screen for inhibitors of the PhoP region in S... -

Data from ChEMBL 36 via Core Engine