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Compound Detail

CHEMBL1611733

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CCCCCCCn1c(=O)c(C(=O)Nc2cnccn2)c(O)c2ccccc21

Basic Information

ChEMBL ID CHEMBL1611733
Phase Preclinical
Structure Type MOL
InChI Key IONTWAIDPPMSMW-UHFFFAOYSA-N
9
Targets
11
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

380.4
MW (Da)
3.72
ALogP
6
HBA
2
HBD
97.1
PSA (Ų)
0.58
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H24N4O3
MW 380.45
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -0.99

Activity Summary

IC50 6 meas. best 5.68
EC50 5 meas. best 5.67

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
X-box-binding protein 1
CHEMBL1741176
IC50 5.68 5.68 2100.0 1
Streptokinase A
CHEMBL1293228
EC50 5.67 5.67 2158.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.54 5.54 2883.0 1
Tumor necrosis factor
CHEMBL1825
IC50 5.5 5.5 3180.0 1
DNA damage-inducible transcript 3 protein
CHEMBL2146304
IC50 5.43 5.43 3680.0 1
Nucleotide-binding oligomerization domain-containing protein 1
CHEMBL1293222
IC50 5.25 5.25 5600.0 1
HEK293
CHEMBL614818
EC50 5.2 5.2 6350.0 1
Streptococcus
CHEMBL612313
EC50 5.18 5.18 6654.0 1
HEK293
CHEMBL614818
IC50 5.16 5.16 6848.0 1
Nucleotide-binding oligomerization domain-containing protein 2
CHEMBL1293266
EC50 5.11 5.11 7830.0 1
Nucleotide-binding oligomerization domain-containing protein 2
CHEMBL1293266
IC50 5.09 5.09 8050.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
X-box-binding protein 1 IC50 = 2100.0 nM 5.68 PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory)... -
Streptokinase A EC50 = 2158.0 nM 5.67 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Streptococcus sp. 'group A' EC50 = 2883.0 nM 5.54 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Tumor necrosis factor IC50 = 3180.0 nM 5.5 PUBCHEM_BIOASSAY: SAR analysis of inhibitors of TNFa specific NF-kB induction re... -
DNA damage-inducible transcript 3 protein IC50 = 3680.0 nM 5.43 PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmator... -
Nucleotide-binding oligomerization domain-containing protein 1 IC50 = 5600.0 nM 5.25 PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD1 revised. (Class of... -
HEK293 EC50 = 6350.0 nM 5.2 PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds th... -
Streptococcus EC50 = 6654.0 nM 5.18 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... -
HEK293 IC50 = 6848.0 nM 5.16 PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds th... -
Nucleotide-binding oligomerization domain-containing protein 2 EC50 = 7830.0 nM 5.11 PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds th... -
Nucleotide-binding oligomerization domain-containing protein 2 IC50 = 8050.0 nM 5.09 PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 revised. (Class of... -

Data from ChEMBL 36 via Core Engine