Compound Detail
CHEMBL1997909
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Cc1ccccc1Nc1nccc(-c2c(-c3cccc(NC(=O)Cc4ccccc4)c3)nc3sccn23)n1
Basic Information
| ChEMBL ID | CHEMBL1997909 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GXKYSFQMTTZPGW-UHFFFAOYSA-N |
8
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
516.6
MW (Da)
6.75
ALogP
7
HBA
2
HBD
84.2
PSA (Ų)
0.25
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 8 meas. best 7.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | Ki | 7.6 | 7.6 | 25.1 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Serine/threonine-protein kinase 3 CHEMBL4708 | Ki | 6.8 | 6.8 | 158.5 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | Ki | 6.7 | 6.7 | 199.5 | 1 |
| Insulin-like growth factor 1 receptor CHEMBL1957 | Ki | 6.7 | 6.7 | 199.5 | 1 |
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | Ki | 6.7 | 6.7 | 199.5 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 5 CHEMBL4852 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 2 CHEMBL5330 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine