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Compound Detail

CHEMBL1310221

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CCOC(=O)C1=C(c2ccc(OC)cc2)C(=O)c2ccccc2C1=O

Basic Information

ChEMBL ID CHEMBL1310221
Phase Preclinical
Structure Type MOL
InChI Key XXVSDVHJZIFLCW-UHFFFAOYSA-N
11
Targets
13
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

336.3
MW (Da)
3.09
ALogP
5
HBA
0
HBD
69.7
PSA (Ų)
0.63
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H16O5
MW 336.34
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.06

Activity Summary

EC50 8 meas. best 6.22
IC50 5 meas. best 6.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Heat shock protein HSP 90-alpha
CHEMBL3880
IC50 6.49 6.49 321.9 1
BJ
CHEMBL614358
EC50 6.22 6.22 605.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.82 5.82 1513.0 1
Streptokinase A
CHEMBL1293228
EC50 5.75 5.75 1780.0 1
Protein RecA
CHEMBL1741171
EC50 5.74 5.74 1830.0 1
Hexokinase HKDC1
CHEMBL1741200
IC50 5.63 5.62 2320.0 2
Unchecked
CHEMBL612545
EC50 5.63 5.54 2328.0 2
Streptococcus
CHEMBL612313
EC50 5.21 5.21 6203.0 1
DNA damage-inducible transcript 3 protein
CHEMBL2146304
IC50 5.05 5.05 8810.0 1
Mannose-6-phosphate isomerase
CHEMBL2758
IC50 4.37 4.37 42448.0 1
Heat shock factor protein 1
CHEMBL5313
EC50 4.28 4.28 52160.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Heat shock protein HSP 90-alpha IC50 = 321.92 nM 6.49 PUBCHEM_BIOASSAY: Luminescence-based dose response biochemical high throughput s... -
BJ EC50 = 605.0 nM 6.22 PUBCHEM_BIOASSAY: Fluorescence Cell-Based Dose Response to Characterize Compound... -
Streptococcus sp. 'group A' EC50 = 1513.0 nM 5.82 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Streptokinase A EC50 = 1780.0 nM 5.75 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Protein RecA EC50 = 1830.0 nM 5.74 PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inh... -
Unchecked EC50 = 2328.0 nM 5.63 PUBCHEM_BIOASSAY: High Throughput Screen to Identify Compounds that Suppress the... -
Hexokinase HKDC1 IC50 = 2320.0 nM 5.63 PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of hexokinase domain ... -
Hexokinase HKDC1 IC50 = 2440.0 nM 5.61 PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of hexokinase domain ... -
Unchecked EC50 = 3567.0 nM 5.45 PUBCHEM_BIOASSAY: High Throughput Screen to Identify Compounds that Suppress the... -
Streptococcus EC50 = 6203.0 nM 5.21 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... -
DNA damage-inducible transcript 3 protein IC50 = 8810.0 nM 5.05 PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmator... -
Mannose-6-phosphate isomerase IC50 = 42448.0 nM 4.37 PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isom... -
Heat shock factor protein 1 EC50 = 52160.0 nM 4.28 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators o... -

Data from ChEMBL 36 via Core Engine