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Compound Detail

CHEMBL1544561

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Br.CCCCCCCCCCCCn1ccc(=N)cc1

Basic Information

ChEMBL ID CHEMBL1544561
Phase Preclinical
Structure Type MOL
InChI Key ANXKJACJVUEQOC-UHFFFAOYSA-N
Parent Compound CHEMBL568092
Active Moiety CHEMBL568092
7
Targets
14
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

262.4
MW (Da)
4.89
ALogP
2
HBA
1
HBD
28.8
PSA (Ų)
0.55
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H31BrN2
MW 343.35
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -0.23

Activity Summary

EC50 9 meas. best 6.02
IC50 5 meas. best 6.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Jurkat
CHEMBL397
IC50 6.04 6.04 920.0 1
BJ
CHEMBL614358
EC50 6.02 5.6025 949.0 4
Galanin receptor type 3
CHEMBL2731
IC50 5.89 5.89 1284.0 1
Unchecked
CHEMBL612545
IC50 5.62 4.9467 2390.0 3
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.51 5.51 3088.0 1
Streptokinase A
CHEMBL1293228
EC50 5.39 5.075 4096.0 2
Unchecked
CHEMBL612545
EC50 5.1 5.1 8008.0 1
Streptococcus
CHEMBL612313
EC50 4.99 4.99 10290.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Jurkat IC50 = 920.0 nM 6.04 PUBCHEM_BIOASSAY: Dose response confirmation of uHTS of chemical inhibitors of b... -
BJ EC50 = 949.0 nM 6.02 PUBCHEM_BIOASSAY: Fluorescence Cell-Based Dose Response to Characterize Compound... -
Galanin receptor type 3 IC50 = 1284.0 nM 5.89 PubChem BioAssay. Fluorescence-based cell-based primary high throughput dose res... -
Unchecked IC50 = 2390.0 nM 5.62 PUBCHEM_BIOASSAY: Dose response counterscreen of uHTS chemical inhibitors of bot... -
BJ EC50 = 2718.0 nM 5.57 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
BJ EC50 = 2847.0 nM 5.55 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Comp... -
Streptococcus sp. 'group A' EC50 = 3088.0 nM 5.51 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Streptokinase A EC50 = 4096.0 nM 5.39 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
BJ EC50 = 5367.0 nM 5.27 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
Unchecked EC50 = 8008.0 nM 5.1 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
Unchecked IC50 = 9190.0 nM 5.04 PUBCHEM_BIOASSAY: Dose response confirmation of uHTS chemical inhibitors of both... -
Streptococcus EC50 = 10290.0 nM 4.99 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... -
Streptokinase A EC50 = 17552.0 nM 4.76 PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify I... -
Unchecked IC50 = 66100.0 nM 4.18 PUBCHEM_BIOASSAY: Dose response cytotoxicity of uHTS chemical inhibitors of both... -

Data from ChEMBL 36 via Core Engine