Compound Detail
CHEMBL1981744
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Basic Information
| ChEMBL ID | CHEMBL1981744 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JUTMUSMWCYHBGU-UHFFFAOYSA-N |
10
Targets
10
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
366.7
MW (Da)
4.95
ALogP
3
HBA
2
HBD
66.9
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 10 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta CHEMBL262 | Ki | 8.1 | 8.1 | 7.9 | 1 |
| Glycogen synthase kinase-3 alpha CHEMBL2850 | Ki | 7.8 | 7.8 | 15.8 | 1 |
| Activin receptor type-1 CHEMBL5903 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Dual specificity protein kinase CLK4 CHEMBL4203 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | Ki | 5.7 | 5.7 | 1995.3 | 1 |
| High affinity nerve growth factor receptor CHEMBL2815 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Tyrosine-protein kinase JAK2 CHEMBL2971 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 1 CHEMBL3587 | Ki | 5.5 | 5.5 | 3162.3 | 1 |
| Tyrosine-protein kinase ABL1 CHEMBL1862 | Ki | 5.4 | 5.4 | 3981.1 | 1 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | Ki | 5.4 | 5.4 | 3981.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine