Compound Detail

CHEMBL60889

MOSAPRIDE

🧪 Phase III

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🧪 Phase III

CCOc1cc(N)c(Cl)cc1C(=O)NCC1CN(Cc2ccc(F)cc2)CCO1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL60889
Name	MOSAPRIDE
Phase	Phase III
Structure Type	MOL
InChI Key	YPELFRMCRYSPKZ-UHFFFAOYSA-N

Known Names

Mosaprida Mosapride Mosart

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

421.9

MW (Da)

3.09

ALogP

HBA

HBD

76.8

PSA (Å²)

0.67

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Racemic

USAN Stem

-pride

Extended Properties

Molecular Formula	C21H25ClFN3O3
MW	421.90
Aromatic Rings	2
Heavy Atoms	29
NP-Likeness	-1.83

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Serotonin 3 (5-HT3) receptor antagonist	ANTAGONIST	Serotonin 3 (5-HT3) receptor	✓	✓
Serotonin 4 (5-HT4) receptor agonist	AGONIST	5-hydroxytryptamine receptor 4	✓	✓

Indications

Constipation Digestive System Diseases Dyspepsia Ileus Irritable Bowel Syndrome Diarrhea Gastritis Rectal Diseases

ATC Classification

A03FA09

mosapride

Level 1: ALIMENTARY TRACT AND METABOLISM

Level 2: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS

Activity Summary

IC50 14 meas. best 6.95

Ki 10 meas. best 7.16

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
5-hydroxytryptamine receptor 4 CHEMBL5017	Ki	7.16	7.0233	69.9	3
5-hydroxytryptamine receptor 4 CHEMBL5017	IC50	6.95	6.5	113.0	2
Sigma non-opioid intracellular receptor 1 CHEMBL287	Ki	6.89	6.89	128.4	1
5-hydroxytryptamine receptor 2B CHEMBL1833	Ki	6.72	6.72	188.3	1
5-hydroxytryptamine receptor 2C CHEMBL225	Ki	6.68	6.68	207.7	1
5-hydroxytryptamine receptor 2B CHEMBL1833	IC50	6.53	6.53	295.9	1
Sigma non-opioid intracellular receptor 1 CHEMBL287	IC50	6.51	6.51	305.6	1
5-hydroxytryptamine receptor 2C CHEMBL225	IC50	6.4	6.4	396.6	1
Cytochrome P450 1A2 CHEMBL3356	IC50	6.4	6.4	400.0	1
Cytochrome P450 3A4 CHEMBL340	IC50	6.16	6.16	700.0	1
Alpha-2B adrenergic receptor CHEMBL1942	Ki	6.06	6.06	871.0	1
Cytochrome P450 2C9 CHEMBL3397	IC50	6.0	6.0	1000.0	1
Cytochrome P450 2C19 CHEMBL3622	IC50	6.0	6.0	1000.0	1
Serotonin 3 (5-HT3) receptor CHEMBL2094116	Ki	5.92	5.92	1189.0	1
Alpha-2A adrenergic receptor CHEMBL1867	Ki	5.86	5.86	1379.8	1
Alpha-2B adrenergic receptor CHEMBL1942	IC50	5.72	5.72	1908.0	1
Sodium-dependent serotonin transporter CHEMBL228	Ki	5.69	5.69	2024.9	1
Alpha-2A adrenergic receptor CHEMBL1867	IC50	5.43	5.43	3679.4	1
Sodium-dependent serotonin transporter CHEMBL228	IC50	5.42	5.42	3811.7	1
Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240	IC50	5.32	5.32	4786.3	2

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
5-hydroxytryptamine receptor 4	Ki	=	69.9	nM	7.16	Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4...	12593651
5-hydroxytryptamine receptor 4	Ki	=	84.0	nM	7.08	Tested for affinity against 5-hydroxytryptamine 4 receptor in the myenteric plex...	12540230
5-hydroxytryptamine receptor 4	IC50	=	113.0	nM	6.95	Inhibitory activity against 5-hydroxytryptamine 4 receptor of guinea pig striatu...	11959005
Sigma non-opioid intracellular receptor 1	Ki	=	128.4	nM	6.89	DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)	-
5-hydroxytryptamine receptor 4	Ki	=	147.0	nM	6.83	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [...	-
5-hydroxytryptamine receptor 2B	Ki	=	188.3	nM	6.72	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: ...	-
5-hydroxytryptamine receptor 2C	Ki	=	207.7	nM	6.68	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: ...	-
5-hydroxytryptamine receptor 2B	IC50	=	295.9	nM	6.53	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: ...	-
Sigma non-opioid intracellular receptor 1	IC50	=	305.6	nM	6.51	DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)	-
5-hydroxytryptamine receptor 2C	IC50	=	396.6	nM	6.4	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: ...	-
Cytochrome P450 1A2	IC50	=	400.0	nM	6.4	DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	-
Cytochrome P450 3A4	IC50	=	700.0	nM	6.16	DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluorome...	-
Alpha-2B adrenergic receptor	Ki	=	871.0	nM	6.06	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscin...	-
5-hydroxytryptamine receptor 4	IC50	=	881.8	nM	6.05	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [...	-
Cytochrome P450 2C19	IC50	=	1000.0	nM	6.0	DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	-
Cytochrome P450 2C9	IC50	=	1000.0	nM	6.0	DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	-
Serotonin 3 (5-HT3) receptor	Ki	=	1189.0	nM	5.92	Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxyt...	12593651
Alpha-2A adrenergic receptor	Ki	=	1379.8	nM	5.86	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	-
Alpha-2B adrenergic receptor	IC50	=	1908.0	nM	5.72	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscin...	-
Sodium-dependent serotonin transporter	Ki	=	2024.9	nM	5.69	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand bind...	-

Literature References

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL3885881	Rattus norvegicus	526
1995885	10.1021/jm00106a023	Rattus norvegicus	4
1995885	10.1021/jm00106a023	Mus musculus	3
37468498	10.1038/s41467-023-40064-9	Thromboxane A2 receptor	2
37468498	10.1038/s41467-023-40064-9	Prostaglandin G/H synthase 1	2
-	10.6019/CHEMBL4808148	Histone deacetylase 6	2
-	10.6019/CHEMBL4651402	SARS-CoV-2	2
37468498	10.1038/s41467-023-40064-9	Muscarinic acetylcholine receptor M1	2
9873469	10.1016/s0960-894x(98)00341-2	Canis familiaris	2
37468498	10.1038/s41467-023-40064-9	Alpha-1A adrenergic receptor	2
19260734	10.1021/jm801236n	Voltage-gated inwardly rectifying potassium channel KCNH2	1
37468498	10.1038/s41467-023-40064-9	Voltage-gated inwardly rectifying potassium channel KCNH2	1
37468498	10.1038/s41467-023-40064-9	D(1A) dopamine receptor	1
-	10.1101/2020.04.03.023846	SARS-CoV-2	1
21185626	10.1016/j.ejmech.2010.11.042	Voltage-gated inwardly rectifying potassium channel KCNH2	1
12593651	10.1021/jm020270n	5-hydroxytryptamine receptor 4	1
12593651	10.1021/jm020270n	Serotonin 3 (5-HT3) receptor	1
11959005	10.1016/s0960-894x(02)00060-4	Canis familiaris	1
11959005	10.1016/s0960-894x(02)00060-4	5-hydroxytryptamine receptor 4	1
12540230	10.1021/jm020099f	5-hydroxytryptamine receptor 4	1

Data from ChEMBL 36 via Core Engine