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Compound Detail

CHEMBL1369594

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O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1

Basic Information

ChEMBL ID CHEMBL1369594
Phase Preclinical
Structure Type MOL
InChI Key SBPLXFJNSSUYKH-QINSGFPZSA-N
5
Targets
13
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

364.9
MW (Da)
5.70
ALogP
3
HBA
1
HBD
45.8
PSA (Ų)
0.37
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H13ClN2OS
MW 364.86
Aromatic Rings 4
Heavy Atoms 25
NP-Likeness -1.36

Activity Summary

EC50 8 meas. best 5.99
IC50 5 meas. best 6.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sphingosine 1-phosphate receptor 4
CHEMBL3230
IC50 6.43 6.28 370.0 2
Unchecked
CHEMBL612545
EC50 5.99 5.4675 1035.0 4
BJ
CHEMBL614358
EC50 5.43 5.2767 3713.0 3
Sphingosine 1-phosphate receptor 1
CHEMBL4333
IC50 5.17 5.17 6770.0 1
Neurotensin receptor type 1
CHEMBL4123
EC50 4.9 4.9 12600.0 1
Unchecked
CHEMBL612545
IC50 4.67 4.56 21190.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Sphingosine 1-phosphate receptor 4 IC50 = 370.0 nM 6.43 PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screenin... -
Sphingosine 1-phosphate receptor 4 IC50 = 737.5 nM 6.13 PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening ass... -
Unchecked EC50 = 1035.0 nM 5.99 PUBCHEM_BIOASSAY: Luminescence Cell-Based/Microorganism Dose Confirmation HTS to... -
BJ EC50 = 3713.0 nM 5.43 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
BJ EC50 = 4269.0 nM 5.37 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
Unchecked EC50 = 4600.0 nM 5.34 PUBCHEM_BIOASSAY: Dose response confirmation of small molecule activators of the... -
Unchecked EC50 = 5275.0 nM 5.28 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
Unchecked EC50 = 5469.0 nM 5.26 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS Screen to Identify C... -
Sphingosine 1-phosphate receptor 1 IC50 = 6770.0 nM 5.17 PUBCHEM_BIOASSAY: Fluorescence-based counterscreen assay for S1P4 antagonists: C... -
BJ EC50 = 9335.0 nM 5.03 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Comp... -
Neurotensin receptor type 1 EC50 = 12600.0 nM 4.9 PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Ag... -
Unchecked IC50 = 21190.0 nM 4.67 PUBCHEM_BIOASSAY: High Throughput Screening Assay used to Identify Novel Compoun... -
Unchecked IC50 = 35480.0 nM 4.45 PUBCHEM_BIOASSAY: A High Throughput Confirmatory Assay used to Identify Novel Co... -

Data from ChEMBL 36 via Core Engine