Compound Detail
CHEMBL256835
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Basic Information
| ChEMBL ID | CHEMBL256835 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZQUSFAUAYSEREK-UHFFFAOYSA-N |
11
Targets
11
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
368.4
MW (Da)
3.63
ALogP
6
HBA
1
HBD
73.1
PSA (Ų)
0.76
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 10 meas. best 7.6
IC50 1 meas. best 4.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Casein kinase I isoform delta CHEMBL2828 | Ki | 7.6 | 7.6 | 25.1 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 4 CHEMBL6166 | Ki | 7.4 | 7.4 | 39.8 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 5 CHEMBL4852 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| Misshapen-like kinase 1 CHEMBL5518 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Casein kinase I isoform alpha CHEMBL2793 | Ki | 6.3 | 6.3 | 501.2 | 1 |
| Mitogen-activated protein kinase 9 CHEMBL4179 | Ki | 6.2 | 6.2 | 631.0 | 1 |
| Tyrosine-protein kinase FRK CHEMBL4223 | Ki | 6.1 | 6.1 | 794.3 | 1 |
| Tyrosine-protein kinase Lck CHEMBL258 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Serine/threonine-protein kinase D3 CHEMBL2595 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Serine/threonine-protein kinase D2 CHEMBL4900 | Ki | 5.3 | 5.3 | 5011.9 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase CHEMBL1906 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18346893 | 10.1016/j.bmcl.2008.02.068 | RAF proto-oncogene serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine