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Compound Detail

CHEMBL1396209

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Cc1ccc(C[n+]2c(-c3ccc(C)cc3)cc(-c3ccc(C)cc3)cc2-c2ccc(C)cc2)cc1.[O-][Cl+3]([O-])([O-])[O-]

Basic Information

ChEMBL ID CHEMBL1396209
Phase Preclinical
Structure Type MOL
InChI Key YXQAVYUNCRWPBM-UHFFFAOYSA-M
Parent Compound CHEMBL1619364
Active Moiety CHEMBL1619364
7
Targets
25
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

454.6
MW (Da)
8.26
ALogP
0
HBA
0
HBD
3.9
PSA (Ų)
0.24
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H32ClNO4
MW 554.09
Aromatic Rings 5
Heavy Atoms 35
NP-Likeness -0.30

Activity Summary

EC50 15 meas. best 6.66
IC50 10 meas. best 6.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.66 5.7971 220.0 7
Unchecked
CHEMBL612545
IC50 6.54 5.1633 290.0 9
BJ
CHEMBL614358
EC50 5.97 5.8167 1068.0 3
Streptokinase A
CHEMBL1293228
EC50 5.44 5.415 3613.0 2
Streptococcus sp. 'group A'
CHEMBL612389
EC50 5.43 5.43 3709.0 1
Streptococcus
CHEMBL612313
EC50 5.1 5.1 7913.0 1
Protein RecA
CHEMBL1741171
EC50 5.09 5.09 8200.0 1
Exodeoxyribonuclease V
CHEMBL2095232
IC50 4.7 4.7 20120.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 220.0 nM 6.66 PUBCHEM_BIOASSAY: A cytotoxicity screen of small molecule inhibitors of the PhoP... -
Unchecked IC50 = 290.0 nM 6.54 PUBCHEM_BIOASSAY: Dose Response selectivity of uHTS chemical inhibitors of T-cel... -
Unchecked EC50 = 793.0 nM 6.1 PUBCHEM_BIOASSAY: Luminescence Cell-Based HTS Dose Confirmation to Identify Inhi... -
BJ EC50 = 1068.0 nM 5.97 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
Unchecked IC50 = 1190.0 nM 5.92 PUBCHEM_BIOASSAY: Dose response counterscreen of uHTS chemical inhibitors of T-c... -
BJ EC50 = 1231.0 nM 5.91 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Comp... -
Unchecked EC50 = 1312.0 nM 5.88 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
Unchecked EC50 = 1625.0 nM 5.79 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response to Identify Inhibitors o... -
Unchecked IC50 = 2350.0 nM 5.63 PUBCHEM_BIOASSAY: Dose response confirmation of uHTS chemical inhibitors of T-ce... -
BJ EC50 = 2704.0 nM 5.57 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compound... -
Unchecked EC50 = 3456.0 nM 5.46 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response to Identify Inhibitors o... -
Streptokinase A EC50 = 3613.0 nM 5.44 PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify I... -
Streptococcus sp. 'group A' EC50 = 3709.0 nM 5.43 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Streptokinase A EC50 = 4058.0 nM 5.39 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... -
Unchecked EC50 = 4405.0 nM 5.36 PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Inhibito... -
Unchecked EC50 = 4670.0 nM 5.33 PUBCHEM_BIOASSAY: Dose response confirmation of small molecule activators of the... -
Streptococcus EC50 = 7913.0 nM 5.1 PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... -
Protein RecA EC50 = 8200.0 nM 5.09 PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inh... -
Unchecked IC50 = 15640.0 nM 4.81 PUBCHEM_BIOASSAY: A counter screen for small molecule screen for inhibitors of t... -
Unchecked IC50 = 15619.0 nM 4.81 PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi... -

Data from ChEMBL 36 via Core Engine