Compound Detail
CHEMBL1976196
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Basic Information
| ChEMBL ID | CHEMBL1976196 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GKQJYCBMMCLAOZ-UHFFFAOYSA-N |
17
Targets
17
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
405.2
MW (Da)
4.97
ALogP
3
HBA
2
HBD
91.3
PSA (Ų)
0.47
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 17 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Nek2 CHEMBL3835 | Ki | 6.9 | 6.9 | 125.9 | 1 |
| Aurora kinase B CHEMBL2185 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 2 CHEMBL5330 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Calcium/calmodulin-dependent protein kinase type 1D CHEMBL5073 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Cyclin-dependent kinase 8 CHEMBL5719 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Cyclin-dependent kinase 9 CHEMBL3116 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | Ki | 5.7 | 5.7 | 1995.3 | 1 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-1 CHEMBL4045 | Ki | 5.7 | 5.7 | 1995.3 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Leukocyte tyrosine kinase receptor CHEMBL5627 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Tyrosine-protein kinase ABL1 CHEMBL1862 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | Ki | 5.5 | 5.5 | 3162.3 | 1 |
| Activin receptor type-1 CHEMBL5903 | Ki | 5.5 | 5.5 | 3162.3 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | Ki | 5.4 | 5.4 | 3981.1 | 1 |
| Mitogen-activated protein kinase 8 CHEMBL2276 | Ki | 5.3 | 5.3 | 5011.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine